Fresh analysis reveals that patients who come off blockbuster weight-loss injections like semaglutide or tirzepatide can put back on shed pounds much more quickly than those who stop conventional lifestyle regimens.
Findings released in a prominent health publication shows that while obese people frequently drop substantial amounts of their body weight while undergoing treatment, the mass returns at an average rate of nearly a kilo each month once they quit.
"Individuals buying these medications should be aware of the potential of rapid rebound weight gain when the therapy ends," warns researcher Dr. Susan Jebb.
That rate of recovery means a reversion to starting weight in about 18 months.
Analyzing Treatments
The analysis, which examined 37 of studies involving thousands of participants, compared the outcomes of the injectable medications with other pills.
Researchers emphasize that individuals who lose weight through dieting typically experience a more gradual creep back—approximately 0.1 kg a month—once they finish.
The Reason for the Fast Rebound
Doctors propose the mode of action of the injections accounts for the accelerated regain.
These medications mimic a body's own chemical called GLP-1, which controls appetite.
"Sustained high doses of the hormone concentrations far above than the body's typical production might result in the body to produce less of its own natural GLP-1, and could lessen responsiveness to its actions," noted Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this medication results in appetite is uncontrolled, making excessive eating far more likely."
A Lifelong Condition?
The NHS suggest the injections for people with obesity-related medical conditions, accompanied by prescribed lifestyle changes.
Many experts argue that, given the significant potential of weight regain, the therapy might need to be life-long.
This opinion is echoed by drug manufacturers, who state that the findings "underscore the long-term nature of excess weight," akin to managing conditions like high blood pressure.
User Accounts
Users who have stopped the jabs explain a intense return of cravings.
"It was like something flipping and I was suddenly extremely hungry," recalled one woman.
The struggle is exacerbated if patients have not established sustainable dietary or behavioural changes during therapy.
Significant Adoption
Survey data show that a significant number of people in the UK have used these injections in the past year, with demand continuing to grow.
- Use is more common among females compared to men.
- The middle-aged age group shows the greatest level of interest.
- A large proportion access the medications through private prescriptions rather than the NHS.
Finally, experts emphasize that while the jabs are effective tools for shedding pounds, they are not a magic solution and long-term success hinges on ongoing behavioural management.
